Combining evidence using p-values: application to sequence homology searches
نویسندگان
چکیده
منابع مشابه
Combining evidence using p-values: application to sequence homology searches
MOTIVATION To illustrate an intuitive and statistically valid method for combining independent sources of evidence that yields a p-value for the complete evidence, and to apply it to the problem of detecting simultaneous matches to multiple patterns in sequence homology searches. RESULTS In sequence analysis, two or more (approximately) independent measures of the membership of a sequence (or...
متن کاملCombining Evidence Using P-values: Application to Sequence Homology Searches Introduction
Motivation: To illustrate an intuitive and statistically valid method for combining independent sources of evidence that yields a p-value for the complete evidence, and to apply it to the problem of detecting simultaneous matches to multiple patterns in sequence homology searches. Results: In sequence analysis, two or more (approximately) independent measures of the membership of a sequence (or...
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A general discussion on combining statistical hypothesis tests is followed by an application involving point source detection in skymaps. The traditional literature on combining statistical tests has concentrated on a regime in which p-values as large as 0.05 are still of interest, and in which it is dangerous to treat tests as truly independent. But for point source detection, very small p-val...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 1998
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/14.1.48